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Sonja Strah-Pleynet, Ph.D.

Technology Specialist

Boston, MA
617-956-5984
[email protected]
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Sonja Strah-Pleynet, Ph.D. Photo

Background

Sonja Strah-Pleynet is a Technology Specialist in Fish & Richardson’s Boston office.

Education

University of Ljubljana 1996
Organic Chemistry , Ph.D.


University of Ljubljana 1993
Organic Chemistry , M.S.


University of Ljubljana 1991
Chemistry , B.S.

Language

  • English
  • German
  • French
  • Italian
  • Slovene

Memberships & Affiliations

Member of the American Chemical Society, Organic and Medicinal Chemistry Divisions

Chair of the Host Local Section Committee for the ACS National Meeting in Boston (2015)

Grant proposal reviewer for the National Science Foundation (2012)

Other Distinctions

Publications 

S. Han, L. Thoresen, X. Zhu, S. Narayanan, J.K. Jung, S. Strah-Pleynet, M. Decaire, K. Choi, Y. Xiong, D. Yue, G. Semple, J. Thatte, M. Solomon, L. Fu, K. Whelan, H. Al-Shamma, J. Gatlin, R. Chen, H. Dang, C. Pride, I. Gaidarov, D. Unett, D. Behan, A. Sadeque, K.A. Usmani, C. Chen, J. Edwards, M. Morgan, R.M. Jones: Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists., Bioorg. Med. Chem. Lett., 2015, 25, 322.

Y. Xiong, B. Ullman, J-S. K.Choi, M. Cherrier, S. Strah-Pleynet, M. Decaire, K. Feichtinger, J. M. Frazer, W. H. Yoon, K. Whelan, E. K. Sanabria, A. J. Grottick, H. Al-Shamma, G. Semple: Identification of Fused Bicyclic Heterocycles as Potent and Selective 5-HT(2A) Receptor Antagonists for the Treatment of Insomnia, Bioorg. Med. Chem. Lett., 2012, 22, 1870.

B. R. Teegarden, H. Li, H. Jayakumar, S. Strah-Pleynet, P. I. Dosa, S. D. Selaya, N. Kato, K. Elwell, J. Davidson, K. Cheng, H. Saldana, J. M. Frazer, K. Whelan, J. Foster, S. Espitia, R. R. Webb, N. R. A. Beeley, W. Thomsen, S. R. Morairty, T. S. Kilduff and H. A. Al-Shamma: Discovery of 1-[3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine2A Inverse Agonists for the Treatment of Insomnia, J. Med. Chem., 2010, 53, 1923.

Y. Xiong, B. R. Teegarden, J-S. K. Choi, S. Strah-Pleynet, M. Decaire, H. Jayakumar, P. I. Dosa, M. D. Casper, L. Pham, K. Feichtinger, B. Ullman, J. Adams, D. Yuskin, J. Frazer, M. Morgan, A. Sadeque, W. Chen, R. R. Webb, D. T. Connolly, G. Semple and H. Al-Shamma: Discovery and Structure−Activity Relationship of 3-Methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): A Highly Selective 5-Hydroxytryptamine2A Receptor Inverse Agonist for the Treatment of Arterial Thrombosis, J. Med. Chem., 2010, 53, 4412.

Y. Xiong, B. Ullman, J-S. K.Choi, M. Cherrier, S. Strah-Pleynet, M. Decaire, P. I. Dosa, K. Feichtinger, B. R. Teegarden, J. M. Frazer, W. H. Yoon, Y. Shan, K. Whelan, E. K. Hauser, A.J. Grottick, G. Semple, H. Al-Shamma: Synthesis and in Vivo Evaluation of Phenethylpiperazine Amides: Selective 5-Hydroxy-tryptamine2A Receptor Antagonists for the Treatment of Insomnia, J. Med. Chem., 2010, 53, 5696.

P. Dosa, S. Strah-Pleynet, H. Jayakumar, M. Casper, M. Decaire, Y. Xiong, J. Lehmann, K. Choi, K. Elwell, A. Wong, R. R. Webb, J. W. Adams, J. Ramirez, J. G. Richman, W. Thomsen, G. Semple and B. Teegarden: Solubilized Phenyl-pyrazole Ureas as Potent, Selective 5-HT2A Inverse agonists and their Application as Antiplatelet Agents, Bioorg. Med. Chem. Lett., 2009, 19, 5486.

A.R. Katritzky, S. Strah, D. O. Tymoshenko, G. Johnson: Synthesis of Pyrido[4,3,2-de]-quinazolines via Nitro-Substituted Tetrahydroquinolines, J. Heterocyclic Chem. 1999, 36, 755.

A.R. Katritzky, S. A. Belyakov, S. Strah, B. Cage, N. S. Dalal: Preparation of Spin-Labeled Styrene Divinylbenzene Copolymers and a New Approach for Quantitative Determination of the Resin Loading Using ESR Spectroscopy, Tetrahedron Lett. 1999, 40, 407.

A.R. Katritzky, S. Strah, S. A. Belyakov: The Preparation of Functionalized Amines and Amides Using Benzotriazole Derivatives and Organozinc Reagents, Tetrahedron 1998, 54, 7167.

L. Selic, S. Strah, R. Toplak, B. Stanovnik: Alkyl 2-[2,2-Disubstituted ethenyl]amino-3-dimethylamino- propenoates in the Synthesis of Heterocyclic Systems. An Alternative Method for the Preparation of 3-Amino-4H-pyrido[1,2-a]pyrimidin-4-ones, Heterocycles 1998, 47, 1017.

S. Strah, B. Stanovnik: Reactions of Methyl (E,Z)-2-(2-Benzoyl-2-ethoxycarbonyl-1-ethenyl)amino-3-dimethylaminopropenoate with Heteroarylhydrazines. 2-(2-Benzoyl-2-ethoxycarbonyl-1-ethenyl)amino-3- heteroarylhydrazonopropanoates and 1-Heteroaryl-4-ethoxycarbonyl-3-phenyl-pyrazoles, J. Heterocyclic Chem. 1997, 34, 1629.

S. Strah, A. Golobic, L. Golic, B. Stanovnik: Alkyl (E,Z)-2-(2-Benzoyl-2-ethoxy-carbonyl-1-ethenyl)amino-3-dimethylaminopropenoates in the Synthesis of Fused Pyrimidinones. A Facile Route to 3-Aminoazino-4H-pyrimidin-4-ones, J. Heterocyclic Chem. 1997, 34, 1511.

S. Strah, B. Stanovnik, S. G. Grdadolnik: Alkyl 2-(2-Benzoyl-2-ethoxycarbonyl-1-ethenyl)amino-3-di-methyl-aminopropenoates in the Synthesis of Heterocyclic Systems, J. Heterocyclic Chem. 1997, 34, 263.

S. Strah, J. Svete, B. Stanovnik: The Synthesis of 5-Substituted 3-Benzoylamino-6-(2-sub-stituted-amino-1-ethenyl)-2H-pyran-2-ones and Their Transformations into 2H-Pyrano3,2-cpyridine Derivatives, J. Heterocyclic Chem. 1996, 33, 751.

S. Strah, J. Svete, B. Stanovnik: Rearrangements of 5-Acetyl-3-benzoylamino-6-(2-dimethyl- amino-1-ethenyl)-2H-pyran-2-one and 3-Benzoyl-6-(2-dimethylamino-1-ethenyl)-5-ethoxy-carbonyl-2H-pyran-2-one into 1-Aminopyridine, Pyrano2,3-bpyridine and Isoxazole Derivatives, J. Heterocyclic Chem. 1996, 33, 1303.

Patents

R.M. Jones, S. Han, L. Thoresen, J-K. Jung, S. Strah-Pleynet, X. Zhu, Y. Xiong, D. Yue: Cannabinoid receptor modulators; US Patent 9,944,606, April 2018.

J. Thatte, A.C. Blackburn, S. Han, R.M. Jones, J-K. Jung, A.G. Montalban, B.B. Pal, J.K. Rueter, S. Strah-Pleynet, L. Thoresen, Y. Xiong, D. Yue, X. Zhu: Cannabinoid receptor modulators; US Patent 9,867,822, January 2018.

B. Teegarden, H. Jayakumar, H. Li, S. Strah-Pleynet, P.I. Dosa: Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto; US Patent 9,775,829, October 2017.

Y. Xiong, M.C. Cherrier, J.S.K. Choi, P.I. Dosa, B.M. Smith, S. Strah-Pleynet, B. Ullman, B. Teegarden: Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto; US Patent 9,732,039, August 2017.

J. Thatte, A.C. Blackburn, S. Han, R.M. Jones, J-K. Jung, A.G. Montalban, B.B. Pal, J.K. Rueter, S. Strah-Pleynet, L. Thoresen, Y. Xiong, D. Yue, X. Zhu: Cannabinoid receptor modulators; US Patent 9,597,340, March 2017.

J. Thatte, A.C. Blackburn, S. Han, R.M. Jones, J-K. Jung, A.G. Montalban, B.B. Pal, J.K. Rueter, S. Strah-Pleynet, L. Thoresen, Y. Xiong, D. Yue, X. Zhu: Cannabinoid receptor modulators; US Patent 9,492,447, November 2016.

Y. Xiong, M.C. Cherrier, J.S.K. Choi, P.I. Dosa, B.M. Smith, S. Strah-Pleynet, B. Ullman, B. Teegarden: Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto; US Patent 9,434,692, September 2016.

B. Teegarden, H. Jayakumar, H. Li, S. Strah-Pleynet, P.I. Dosa: Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto; US Patent 9,273,035, March 2016.

B. Teegarden, D. Chapman, M. Decaire, P.I. Dosa, K. Feichtinger, H. Jayakumar, T-A. Tran, S. Strah-Pleynet, J. Xu: Ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto; US Patent 9,221,755, December 2015.

B. Teegarden, D. Chapman, M. Decaire, P.I. Dosa, K. Feichtinger, H. Jayakumar, T-A. Tran, S. Strah-Pleynet, J. Xu: Ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto; US RE45,337, January 2015, Reissue of US Patent 8,148,418, April 2012.

B. Teegarden, H. Jayakumar, H. Li, S. Strah-Pleynet, P.I. Dosa: Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto; US Patent 8,871,797, October 2014.

B. Teegarden, Y. Xiong, S. Strah-Pleynet, H. Jayakumar, P.I. Dosa, K. Feichtinger, M. Casper, J. Lehmann, R.M. Jones, D.J. Unett, J.S.K. Choi: 3-Phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto; US Patent 8,785,441, July 2014.

R.M. Jones, S. Han, L. Thoresen, J-K. Jung, S. Strah-Pleynet, X. Zhu, Y. Xiong, D. Yue: Cannabinoid receptor modulators; US Patent 8,778,950, July 2014.

B. Teegarden, H. Jayakumar, H. Li, S. Strah-Pleynet, P.I. Dosa: Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto; US Patent 8,754,238, June 2014.

B. Teegarden, D. Chapman, M. Decaire, P.I. Dosa, K. Feichtinger, H. Jayakumar, T-A. Tran, S. Strah-Pleynet, J. Xu: Ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto; US Patent 8,680,119, March 2014.

B. Teegarden, Y. Xiong, S. Strah-Pleynet, H. Jayakumar, P.I. Dosa, K. Feichtinger, M. Casper, J. Lehmann, R.M. Jones, D.J. Unett, J.S.K. Choi: 3-Phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto; US Patent 7,884,101, February 2011.

N.R.A. Beeley, D.P. Behan, D.T. Chalmers, F. Menzaghi, S. Strah-Pleynet: Small molecule modulators of G protein-coupled receptor six; US Patent 6,420,563, July 2002.

Presentations

S. Strah-Pleynet, B. Teegarden, S.D. Selaya, H. Jayakumar, W. Thomsen, H. Reyes, R.R. Webb, N.R.A. Beeley: Bioisosteric Modifications of Urea Derivatives as 5-HT2A Inverse-Agonists; Book of Abstracts, MEDI-042. 229th ACS National Meeting, San Diego, California, U.S.A., 2005.

H. Jayakumar, B. Teegarden, S. Strah-Pleynet, S.D. Selaya, N. Kato, K. Elwell, J. Davidson, Y.-J. Shin, W. Thomsen, H. Reyes, F. Menzaghi, K. Whelan, R.R. Webb, N.R.A. Beeley: Synthesis and Structure-Activity Relationships of Substituted Diphenylamines as 5-HT2A Inverse-Agonists; Book of Abstracts, MEDI-049. 229th ACS National Meeting, San Diego, California, U.S.A., 2005.

S. Strah-Pleynet, B. Teegarden, K. Drouet, H. Jayakumar, W. Thomsen, H. Reyes, J. Foster, P. Maffuid, Elwell, K. Feictinger, J. Davidson, S.D. Selaya, N. Kato, Y.-J. Shin, D. Seconi, R. Foster, J. Smith, F. Menzaghi, K. Whelan, D. Behan, D. Chalmers, N.R.A. Beeley: Discovery and Structure-Activity Relationships of Novel 5-HT2A Receptor Inverse-Agonists; Book of Abstracts, MEDI-270. 227th ACS National Meeting, Anaheim, California, U.S.A., 2004.

G. Semple, B. Kramer, D. Hsu, M. Casper, S. Strah-Pleynet, W. Thomsen, T.-A. Tran, C. Bjenning, K. Whelan, K. Kanuma, K. Omodera, M. Nishiguchi, T. Funakoshi, S. Chaki, Y. Sekiguchi: Identification and Biological Activity of a New Series of Antagonists of hMCH-R1; Book of Abstracts, MEDI-007. 228th ACS National Meeting, Philadelphia, Pennsylvania, U.S.A., 2004.

B. Kramer, T.-A. Tran, D. Hsu, M. Casper, S. Strah-Pleynet, N. Beeley, W. Thomsen, I.-L. Lin, K. Kanuma, K. Omodera, M. Nishiguchi, T. Funakoshi, S. Chaki, Y. Sekiguchi: SAR of a Series of 2-Substituted 4-Aminoquinazolines: Antagonists of hMCH-R1; Book of Abstracts, MEDI-054. 228th ACS National Meeting, Philadelphia, Pennsylvania, U.S.A., 2004.

Y. Sekiguchi, K. Kanuma, K. Omodera, M. Nishiguchi, T. Funakoshi, S. Chaki, B. Kramer, D. Hsu, M. Casper, S. Strah-Pleynet, G.. Semple, N. Beeley, W. Thomsen, I.-L. Lin, T.-A. Tran: Identification of ATC0175 (AR224349) as a Potent Antagonist of hMCH-R1; Book of Abstracts, MEDI-053. 228th ACS National Meeting, Philadelphia, Pennsylvania, U.S.A., 2004.

K. Kanuma, Y. Sekiguchi, K. Omodera, M. Nishiguchi, T. Funakoshi, S. Chaki, B. Kramer, D. Hsu, M. Casper, S. Strah-Pleynet, G.. Semple, N. Beeley, W. Thomsen, I.-L. Lin, T-A. Tran: Identification of ATC0065 as a Potent Antagonist of hMCH-R1; Book of Abstracts, MEDI-052. 228th ACS National Meeting, Philadelphia, Pennsylvania, U.S.A., 2004.

S. Strah, J. R. Beadle, K. A. Aldern, K.Y. Hostetler: Effect of Alkoxy Chain Length on the in vitro Antiviral Activity of Ganciclovir Monophosphate Alkoxypropyl Esters; Book of Abstracts, MEDI-288. 218th ACS National Meeting, New Orleans, Louisiana, U.S.A., 1999.

S. Strah, A. R. Katritzky, S. A. Belyakov: New Preparation of Tertiary Amines and Amides Using Benzotriazole Derivatives and Organozinc Reagents; Book of Abstracts, ORG-191. 215th ACS National Meeting, Dallas, Texas, U.S.A., 1998.

S. Strah, A. R. Katritzky, S. A. Belyakov, B. Cage, and N. S. Dalal: Preparation of Spin-Labeled Styrene-Divinylbenzene Copolymers and Their Application Towards Resin Loading Determination; 8th Symposium on the Latest Trends in Organic Synthesis, Gainesville, Florida, U.S.A., 1998.

S. Strah, B. Stanovnik: ,-Didehydro--amino Acids in the Synthesis of Heterocyclic Systems; 17th European Colloquium on Heterocyclic Chemistry, Regensburg, Germany, 1996.

S. Strah, B. Stanovnik: Studies on the Isomerisation of the Substituted Pyrano[3,2-c]pyridine and Pyrano[2,3-b]pyridine; 9th European Symposium on Organic Chemistry, Warsaw, Poland, 1995.

B. Stanovnik, J. Svete, A. Hvala, M Kmetic, L. Kralj, L. Selic, J. Smodis, G. Sorsak, S. Strah, R. Toplak: New Reagents in the Synthesis of Heterocyclic Systems. The Synthesis and Transformations of Substituted 2-Amino- and 2-Hydroxy-3-dimethylaminopropenoates; 9th International Congress of Heterocyclic Chemistry, Taipei, Taiwan, 1995.

S. Strah, B. Stanovnik: Fused Pyranones in the Synthesis of -Heterocyclic--amino Acids and Derivatives; 16th European Colloquium on Heterocyclic Chemistry, Bled, Slovenia, 1994.

S. Strah, B. Stanovnik, M. Tisler: A Novel Synthesis of 2H-Pyrano[3,2-c]pyridine Derivatives; 5th Graz-Ljubljana-Trieste Symposium on Organic Chemistry, Brdo, Kranj, Slovenia, 1994.

S. Strah, B. Stanovnik, M. Tisler: 5,6-disubstituted 3-Benzoylamino-2H-pyran-2-ones in the Synthesis of Heterocyclic Systems; 8th European Symposium on Organic Chemistry, Sitges, Barcelona, Spain, 1993.

Aljaz-Rozic, B. Stanovnik, S. Strah, J. Svete, M. Tisler: The Synthesis of N-[(2-Phenyl-5-oxo-oxazolinyl-4)-methylene]amino Acid Derivatives; 4th Graz-Ljubljana-Trieste Symposium on Organic Chemistry, Trieste, Italy, 1991.

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