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Hanchao Zhao, Ph.D.

Technology Specialist, Patent Agent

Boston, MA
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617-368-2182
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hzhao@fr.com
Hanchao Zhao, Ph.D. Photo
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About Hanchao

Hanchao Zhao is a technology specialist and patent agent in the Boston office of Fish & Richardson P.C. His practice focuses on patent drafting, prosecution and counseling in broad aspects of life sciences, including biochemistry, biophysics, molecular biology, cell biology, microbiology, structural and computational biology, small-molecule drug discovery, antibody development, cancer therapies and high-throughput sequencing technologies.

Dr. Zhao received his Ph.D. in biochemistry from the University of Illinois at Urbana-Champaign, where he collaborated with pharmaceutical companies and academic labs to investigate small-molecule drug inhibition mechanisms, using both experimental and theoretical methods. He also developed and optimized a platform to efficiently track protein/nucleic acid movement in bacteria by ultracentrifugation. Upon finishing his Ph.D., Dr. Zhao was recruited to Scripps Research in La Jolla, California, to continue his research on RNA-interacting proteins. At Scripps, he developed bio-analytical and cell-based methods to understand host-microbe communications. Dr. Zhao has co-authored multiple research articles in top-tier journals and given presentations/posters at international conferences. His previous experience also includes working at Tsinghua University in Beijing and collaborating at the University of Tokyo in Japan.

 

Publications 

  • Kim, J.H.; Lee, C.L.; Wang, H.; Kim, K.; Seung, J.P.; Yoon, I.; Jang, J.; Zhao, H.; Kim, H.K.; Kwon, N.H.; Jeong, S.J.; Yoo, H.C.; Kim, J.H.; Yang, J.S.; Lee, M.Y.; Lee, C.W.; Yun, J.; Oh, S.J.; Kang, J.S.; Martinis, S.A.; Hwang, K.Y.; Guo, M.; Han, G.; Han, J.M.; Kim, S, “Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction.” Nature Communications. 2017, 8(1), 732.
  • Buechler, A.K.; Zhao, H.; Lieu, D.J.; Blanke, S.R.; Martinis, S.A. “Escherichia coli tRNA induces mammalian cell migration and socialization.” The FASEB Journal. 2017, 31 (1 Supplement), 622.14.
  • Zhao, H.; Martinis, S.A. “Isolation of bacterial compartments to track movement of protein synthesis factors.” Methods. 2017, 113, 120-126.
  • Zhao, H.; Palencia, A.; Seiradake, E.; Ghaemi, Z.; Cusack, S.; Luthey-Schulten, Z.; Martinis, S.A. “Analysis of the resistance mechanism of a benzoxaborole inhibitor reveals insight into the leucyl-tRNA synthetase editing mechanism.” ACS Chemical Biology. 2015, 10 (10): 2277-85.
  • Shan, S.; Chen, X.; Liu, T.; Zhao, H.; Rao, Z.; Lou, Z. “Crystal structure of 4-diphosphocytidyl-2-C-methyl-Derythritol-kinase (IspE) from Mycobacterium tuberculosis.” The FASEB Journal. 2011, 25 (5):1577-84.

Speaking Engagements

  • Zhao, H.; Buechler, A.K.; Martinis, S.A. “Re-purposing of leucyl-tRNA synthetase for Nutritional stress responses,” Conference Talk at 2017 IUBMB focused Meeting on Aminoacyl-tRNA Synthetases (AARS2017) Clearwater Beach, Florida (October 2017)
  • Martinis, S.A.; Zhao, H.; Buechler, A.K. “Re-purposing of ancient protein synthesis enzyme and RNAs for cell signaling,” Conference Talk at Spiegelman Symposium, Urbana, Illinois (October 2017)
  • Buechler, A.K.; Zhao, H.; Lieu, D.J.; Blanke, S.R.; Martinis, S.A.  “Escherichia coli tRNA induces mammalian cell migration and socialization,” Conference poster at ASBMB annual meeting, Chicago, Illinois (April 2017)
  • Zhao, H.; Martinis, S.A. “Escherichia coli secretion of leucyl-tRNA synthease,” Conference Talk at 10th International symposium on Aminoacyl-tRNA Synthetases (AARS2015) Barcelona, Spain (October 2015)
  • Zhao, H.; Martinis, S.A. “Trafficking of leucyl-tRNA synthetase in E. coli,” Conference Talk at Gordon Research Conference: Translation Machinery in Health & Disease, Ventura, California (February 2015)
  • Banerjee, A.; Zhao, H.; Martinis, S.A.; Saks, M.E. “Intra-organism variation in tRNA structural type,” Poster at the 25th tRNA Conference, Kyllini, Greece (September 2014)
  • Zhao, H.; Palencia, A.; Cusack, S.; Luthey-Schulten, Z.A.; Martinis, S.A. “Regulation of post-transfer editing by a tyrosine switch,” Conferences talk at 9th International Symposium on Aminoacyl-tRNA Synthetases (AARS2013) Hakone, Japan (October 2013)
  • Zhao, H.; Martinis, S.A. “Post-transfer editing of Candida albicans leucyl-tRNA synthetase is sensitive to a lysine that is distal to the editing pocket,” Poster at the 24th tRNA Conference, Olmue, Chile (December 2012)
Focus Areas

Services

Industries

Education

Ph.D., Biochemistry, University of Illinois at Urbana-Champaign (2016)


B.S., Biological Sciences, Tsinghua University (2010)

Admissions
  • U.S. Patent and Trademark Office 2019
Languages
  • English
  • Mandarin Chinese
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