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Santosh V. Coutinho, Ph.D.


Wilmington, DE
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Santosh V. Coutinho is an Associate in the Delaware office of Fish & Richardson. His practice is focused on intellectual property litigation and patent litigation across a broad range of technologies, and includes substantial experience in Hatch-Waxman litigation. Prior to joining the firm, Dr. Coutinho was a Senior Medical Liaison at Novo Nordisk and also worked as a scientist and Medical Science Liaison at Johnson & Johnson. He is also the author of numerous scientific publications and abstracts.​


J.D., Temple University Beasley School of Law 2010

Ph.D., University of Iowa 1998

B.S., University of Bombay 1993
with distinction


  • U.S. Patent and Trademark Office 2010
  • Delaware 2010
  • Pennsylvania 2011

Memberships & Affiliations

Delaware Chapter of the Federal Bar Association, Member
South Asian Bar Association of Delaware, Board Member
Temple Journal of Science, Technology and Environmental Law, Staff Member, 2008 – 2009​

Other Distinctions

Recipient of the Jack M. Golden and Frieda Golden Prize for superior legal research and writing in the area of health care law and health administration.

Selected Publications
“License to Promote, or Just What the Doctor Ordered? The New FDA Guidance on Dissemination of Off-Label Reprints by Pharmaceutical Companies,” Temple Journal of Science, Technology & Environmental Law, Fall 2009.

Breslin, H.J., Cai, C., Miskowski, T.A., Coutinho, S.V., Zhang, S.P., Hornby, P., and He, W. Identification of potent phenyl imidazoles as opioid receptor agonists. Bioorg. Med. Chem. Lett. 16(9):2505-2508, 2006.

Mulugeta, M., Wang, L., Wang, Y., Adelson, D.W., Yuan, P., Maillot, C., Coutinho, S.V., McRoberts, J.A., Bayati, A., Mattsson, H., Wu, V.S., Wei, J.Y., Rivier, J., Vale, W., Mayer, E.A., and Taché, Y. CRF2 receptor activation prevents colorectal distension-induced visceral hyperalgesia and spinal ERK1/2 phosphorylation in rats. Gut, 55(2): 172-181, 2006.

Schwetz,I., McRoberts,J.A., Coutinho,S.V., Bradesi,S., Gale,G., Fanselow,M., Million,M., Ohning,G., Tache,Y., Plotsky,P.M., and Mayer,E.A. Corticotropin-releasing factor receptor 1 mediates acute and delayed stress-induced visceral hyperalgesia in maternally separated Long-Evans rats. Am.J.Physiol Gastrointest.Liver Physiol, 289:G704-G712, 2005.

Breslin, H.J., Miskowski, T.A., Rafferty, B.M., Coutinho, S.V., Palmer, J.M., Wallace, N.H., Schneider, C.R., Kimball, E.S., Zhang, S., Li, J., Colburn, R.W., Stone, D.J., Martinez, R.P., and He, W. Rationale, Design, and Synthesis of Novel Phenyl Imidazoles as Opioid Receptor Agonist for GI Disorders. J.Med.Chem., 47(21): 5009-5020, 2004.

Coutinho, S.V., Plotsky, P.M., Sablad, M., Miller, J.C., Zhou, H., Bayati, A.I., McRoberts, J.A. and Mayer, E.A. Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat. Am. J. Physiol. Gastrointest. Liver Physiol. 282(2):G307-16, 2002.

Mayer, E.A., Naliboff, B.D., Chang, L. and Coutinho, S.V. Stress and Irritable Bowel Syndrome, In: Am. J. Physiol. Gastrointest. Liver Physiol., 280(4):G519-24, 2001.

Coutinho, S.V., Urban, M.O. and Gebhart, G.F. The role of CNS NMDA receptors and nitric oxide in visceral hyperalgesia. Eur J Pharmacol. 429(1-3):319-325, 2001.

McRoberts, J.A., Coutinho, S.V., Marvizón, J.C., Grady, E.F., Tognetto, M., Sengupta, J.N., Ennes, H.S., Chaban, V.V., Amadesi, S., Creminon, C., Lanthorn, T., Geppetti, P., Bunnett, N.W. and Mayer, E.A. Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats. Gastroenterology 120(7):1737-1748, 2001.

Gschossmann, J.M., Coutinho, S.V., Miller, J.C., Hübel, K., Naliboff, B., Wong, H.C., Walsh, J.H. and Mayer, E.A. Involvement of spinal calcitonin gene-related peptide in the development of acute visceral hyperalgesia in the rat. J. Neurogastroenterol. Motil. 13(3):229-236, 2001.

Coutinho, S.V., Su, X., Sengupta, J.N. and Gebhart GF. Role of sensitized pelvic nerve afferents from the inflamed rat colon in the maintenance of visceral hyperalgesia, In: Sandkuhler, J., Bromm, B. and Gebhart, G.F. (Eds.), Nervous System Plasticity and Chronic Pain, Prog. in Brain Research, Vol. 129, Elsevier, Amsterdam, 2000, pp. 375-387.

Urban, M.O., Coutinho, S.V. and Gebhart, G.F. Involvement of excitatory amino acid receptors and nitric oxide in the rostral ventromedial medulla in modulating secondary hyperalgesia produced by mustard oil. Pain 81:45-55, 1999.

Urban, M.O., Coutinho, S.V. and Gebhart, G.F. Biphasic modulation of visceral nociception by neurotensin in the rostral ventromedial medulla. J. Pharmacol. Exp. Ther. 290:207-213, 1999.

Coutinho, S.V. and Gebhart, G.F. A role for spinal nitric oxide in mediating visceral hyperalgesia in the rat. Gastroenterology 116:1399-1408, 1999.

Coutinho, S.V., Urban, M.O. and Gebhart, G.F. Role of glutamate receptors and nitric oxide in the rostral ventromedial medulla in visceral hyperalgesia. Pain 78:59-69, 1998.

Coutinho, S.V., Meller, S.T. and Gebhart, G.F. Intracolonic zymosan produces visceral hyperalgesia in the rat that is mediated by spinal NMDA and non-NMDA receptors. Brain Res. 736:7-15, 1996.

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