Search Team

Search by Last Name
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

Leah Randles, Ph.D.

Technology Specialist

Minneapolis, MN
(612) 638-5784
randles@fr.com
Download vCard
Leah Randles, Ph.D. Photo

Background

Leah Randles is a Technology Specialist in Fish & Richardson’s Twin Cities office. Her practice supports patent prosecution in biochemistry, molecular biology, and pharmaceutical areas. Prior to working at Fish, Dr. Randles completed a postdoctoral fellowship at the National Cancer Institute and also has industry experience through working at a vaccine development company.

Education

Ph.D., University of Minnesota 2012
Biochemistry, Molecular Biology and Biophysics


B.S., University of Minnesota 2006
Genetics, Cell Biology and Development
magna cum laude

Memberships & Affiliations

American Intellectual Property Law Association (AIPLA)
Minnesota Intellectual Property Law Association (MIPLA)
Medical Alley Association (MAA)
Project Management Institute (PMI)

Other Distinctions

Publications

Lu, X., Nowicka, U., Sridharan, V., Liu, F., Randles, L., Hymel, D., Dyba, M., Tarasov, S., Tarasova, N., Zhao, X.Z., Hamazaki, J., Murata, S., Burke, T., and Walters, K.J. “Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets.” Nature Communications 8, 15540 (2017).

Chen, X.*, Randles, L.*, Liu, F., Shi, K., Aihara, H., Tarasov, S.G., and Walters, K.J. “Substrate receptors in the proteasome use ubiquitin-binding sites to also recognize ubiquitin shuttle factors.” Structure 24, 1257-70 (2016).

 Randles, L., Anchoori, R.K., Roden, R.B.S., and Walters K.J. “Proteasome Ubiquitin Receptor hRpn13 and its Interacting Deubiquitinating Enzyme Uch37 are Required for Proper Cell Cycle Progression.” JBC 291, 8773-83 (2016).

Nowicka, U., Hoffman, M., Randles, L., Darwin, K.H., Walters, K.J. “Mycobacterium tuberculosis copper-regulated protein SocB is an intrinsically disordered protein that folds upon interaction with a synthetic phospholipid bylayer.” Proteins, 84, 193-200 (2015).

Hennig, J., de Vries, S., Hennig, K.D.M., Randles, L., Walters, K.J., Sunnerhagen, M., Bonvin, A.M.J.J. “MTMDAT-HADDOCK: high-throughput, data-driven protein complex structure modeling.” BMC Structural Biology 12, (2012).

Randles, L. and Walters, K.J. “Ubiquitin and its binding domains.” Frontiers in Bioscience 17, 2140-2157 (2012).

Zhang, N.*, Wang, Q.*, Ehlinger, A.*, Randles, L.*, Lary, J.W., Kang, Y., Haririnia, A., Storaska, A.J., Cole, J.L., Fushman, D., Walters, K.J. “Structure of the S5a:K48-linked diubiquitin complex and its interactions with Rpn13.” Mol. Cell. 35, 280-90 (2009).

Husnjak, K.*, Elsasser, S.*, Zhang, N.*, Chen, X., Randles, L., Hofmann, K., Walters, K., Finley, D., Dikic, I. “Proteasome subunit Rpn13 is a novel ubiquitin receptor.” Nature 453, 481-8 (2008).

Schreiner, P.*, Chen, X.*, Husnjak, K.*, Randles, L., Zhang, N., Elsasser, S., Finley, D., Dikic, I., Walters, K., Groll, M. “Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction.” Nature 453, 548-52 (2008).

Services

Industries