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Kathleen Fleming, Ph.D.

Technology Specialist

Boston, MA
617-368-2141
fleming@fr.com
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Kathleen Fleming, Ph.D. Photo

Background

Kathleen Fleming is a Technology Specialist in the Boston Office of Fish & Richardson.

Dr. Fleming supports client counseling and patent prosecution in biotechnology, chemical engineering, and biological engineering.  She has experience drafting and/or prosecuting patent applications concerning:

  • Gene editing methods (e.g., CRISPR);
  • Methods to alter gene expression (e.g., those that alter post-translational modifications of select DNA-associated proteins, alter localization of repressors or activators, or sterically block localization of proteins);
  • Biologic compositions (e.g., chemically modified polynucleotides, chimeric or fusion polypeptides, or lipid encapsulated polypeptides);
  • Chemical engineering processes (e.g., synthesis of drugs, synthesis of oligonucleotides, lyophilization of compositions, or deposition of chemical layers onto particles or surfaces); and
  • Biological engineering processes (e.g., use of enzymes to modify protein post-translational modifications or growing cells to produce recombinant proteins).

In addition to filing and prosecuting domestic and international patent filings, Dr. Fleming provides assistance with due diligence, freedom-to-operate, and landscape review.

Dr. Fleming completed her doctoral studies in biochemistry at Harvard University and undergraduate studies in chemical-biological engineering at Massachusetts Institute of Technology.  Her doctoral research, with Dr. Erin O’Shea, elucidated a transcription factor cascade using genetics and biochemical assays, including assays coupled to high-throughput sequencing (e.g. ChIP-seq and RNA-seq).  Her undergraduate research, in courses and labs of MIT professors, included designing polymer films to release antimicrobial peptides, operating (and modeling performance) of bioreactors with genetically modified bacteria, modeling chemical reactions in continuous and batch reactors, purifying recombinant proteins and performing radioactive and spectrometric activity assays.  Prior to starting graduate school, Kathleen worked on a functional genomics team at Dana-Farber Cancer Institute to probe gene interaction networks by performing a series of RNA interference experiments.  Following graduate school, she worked at a Boston-based biotech company where she performed CRISPR experiments and contributed as an inventor to several provisional patent applications.

Education

Ph.D., Harvard University 2017
Biochemistry


M.S., Harvard University 2013
Biology


S.B., Massachusetts Institute of Technology 2011
Chemical-Biological Engineering

Other Distinctions

Publications and Presentations 

Fleming K and O’Shea EK. (2018). An RpaA-Dependent Sigma Factor Cascade Sets the Timing of Circadian Transcriptional Rhythms in Synechococcus elongatus. Cell Reports, 25(11): 2937-2945. 10.1016/j.celrep.2018.11.049

Fleming K and O’Shea E. A clock-phased sigma factor cascade times global circadian transcriptional rhythms in cyanobacteria. Invited student speaker at the Boston Bacterial Meeting (June 2017).

Olsen C, Fleming K, Prendergast N, Rubio R, Emmert-Streib F, Bontempi G, Quackenbush J, Haibe-Kains B. (2015). Using shRNA experiments to validate gene regulatory networks. Genom Data, 4,123-6. 10.1016/j.gdata.2015.03.011

Olsen C, Fleming K, Prendergast N, Rubio R, Emmert-Streib F, Bontempi G, Haibe-Kains B, Quackenbush J. (2014). Inference and validation of predictive gene networks for biomedical literature and gene expression data. Genomics, 103, 329-336. 10.1016/j.ygeno.2014.03.004

Shukla A, Fleming K, Chuang H, Chau T, Loose C, Stephanopoulos G, Hammond P. (2010). Controlling the release of peptide antimicrobial agents from surfaces. Biomaterials, 3, 2348-2357. 10.1016/j.biomaterials.2009.11.082

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