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Justine N. deGruyter, Ph.D.

Technology Specialist

Minneapolis, MN
(612) 638-5768
deGruyter@fr.com
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Justine N. deGruyter, Ph.D. Photo

Background

Justine N. deGruyter, Ph.D. is a Technology Specialist in Fish & Richardson’s Twin Cities office. Dr. deGruyter completed her graduate studies at The Scripps Research Institute, where she developed new methods for the synthesis and modification of therapeutic biomolecules in collaboration with various pharmaceutical partners.

Education

Ph.D., Scripps Research 2018
Organic Chemistry


B.S., New Mexico State University 2014
Chemistry

Other Distinctions

Peer-Reviewed Journal Articles

Smith, J. M.; Dixon, J. A.; deGruyter, J. N.; Baran, P. S. DiversinatesTM: Radical precursors enabling drug
discovery, J. Med. Chem. Invited perspective, under review.

Ni, S.; Garrido-Castro, A. F.; Merchant, R. R.; deGruyter, J. N.; Schmitt, D. C.; Mousseau, J. J.; Gallego, G.
M.; Yang, S.; Collins, M. R.; Qiao, J. X.; Yeung, K.-S.; Langley, D. R.; Poss, M. A.; Scola, P. M.; Ewing, W. R.;
Qin, T.; Baran, P. S. A general amino acid synthesis enabled by innate radical cross-coupling, Angew. Chem. Int.
Ed. 2018, accepted.

Knouse, K. W.*; deGruyter, J. N.*; Schmidt, M. A.; Zheng, B.; Vantourout, J. C.; Kingston, C.; Mercer, S.
E.; Mcdonald, I. M.; Olson, R. E.; Zhu, Y.; Hang, C.; Zhu, J.; Yuan, C.; Wang, Q.; Park, P.; Eastgate, M. D.;
Baran, P. S. Unlocking P(V): Reagents for chiral phosphorothioate synthesis, Science 2018, DOI: 10.1126/
science.aau3369.

deGruyter, J. N. Functionalized peptides: Ideal targets for collaborative chemistry, Biochemistry 2018, 57,
2745–2746.

Schmidt, M. A.; Knouse, K. W.; deGruyter, J. N.; Zheng, B.; Ewing, W.; Eastgate, M. D.; Baran, P. S. Novel
phosphorous (V)-based reagents for the preparation thereof, and their use in making stereo-defined
organophosphorous (V) compounds. (2018) Provisional USPTO Application #62657551.

deGruyter, J. N.*; Malins, L. R.*; Wimmer, L.; Clay, K. J.; Lopez-Ogalla, J.; Qin, T.; Cornella, J.; Liu, Z.;
Che, G.; Bao, D.; Stevens, J. M.; Qiao, J.; Allen, M. P.; Poss, M. A.; Baran, P. S. CITU: A peptide and
decarboxylative coupling reagent, Org. Lett. 2017, 19, 6196–6199.

Pflueger, J. J.; Morrill, L. C.; deGruyter, J. N.; Perea, M. A.; Sarpong, R. A magnesiate addition/ringexpansion
strategy to access the 6–7–6 tricyclic core of hetisine-type C20-diterpenoid alkaloids, Org. Lett. 2017,
19, 4632–4635.

deGruyter, J. N.*; Malins, L. R.*; and Baran, P. S. Residue-specific peptide modification: A chemist’s guide,
Biochemistry 2017, 56, 3863–3873.

Malins, L. R.*; deGruyter, J. N.*; Robbins, K. J.; Scola, P. M.; Eastgate, M. D.; Ghadiri, M. R.; Baran, P. S.
Peptide macrocyclization inspired by non-ribosomal imine natural products, J. Am. Chem. Soc. 2017, 139, 5233–
5241.

deGruyter, J. N. and Maio, W. A. The taumycin A macrocycle: Asymmetric total synthesis and revision of
relative stereochemistry, Org. Lett. 2014, 16, 5196–5199.

Honors and Awards

Gewirtz Memorial Scholarship, Oligonucleotide Therapeutics Society (2018).
CAS SciFinder® Future Leaders Award (2018).
WCC Merck Research Award (2018).
Bristol-Myers Squibb Graduate Fellowship in Synthetic Organic Chemistry (2017).
Fletcher Jones Foundation Fellowship, TSRI (2014).
Graduate Research Fellowship, National Science Foundation (2014).
Darleane Hoffman Award, NMSU (2014).
College of Arts and Sciences Outstanding Senior Award, NMSU (2014).
Amgen Scholars Program, University of California, Berkeley (2013).
McKnight Chemistry Grand Prize, University of Texas, Southwestern (2013).
College of Arts and Sciences Outstanding Junior Award, NMSU (2013).
Elizabeth B. Corbett Scholarship, NMSU (2013).
Latimer Evans Award, NMSU (2012).
Devasthali Outstanding Sophomore Award, NMSU (2012).
Kennett G. Melgaard Award, NMSU (2011).
Elizabeth B. Corbett Scholarship, NMSU (2011).

Presentations 

ACS National Meeting and Exposition, Boston, MA (August 2018)
Oral: Aiming for Ideality in the Age of Biomolecules

Bristol-Myers Squibb Graduate Research Symposium, Princeton Pike, NJ (April 2018)
Oral: Aiming for Ideality in the Age of Biomolecules

McKnight Chemistry Competition, UTSW, New Braunsfels, TX (November 2013)
Poster: Asymmetric Total Synthesis and Relative Stereochemistry of the Taumycin A Macrocycle
(First Place)

Amgen Scholars Symposium, Berkeley, CA (August 2013)
Oral: Studies Toward the Heptacyclic Core of the C20-Diterpenoid Alkaloids

ACS National Meeting and Exposition, New Orleans, LA (April 2013)
Poster: Synthetic Studies Towards the Total Synthesis of Taumycin A